The Enzymatic Degradation of Heme Proteins into Bile Pigments
نویسندگان
چکیده
منابع مشابه
The Enzymatic Degradation of Hemoglobin to Bile Pigments by Macrophages
Recent studies have identified and characterized the enzymatic mechanism by which hemoglobin-heme is converted to bilirubin. Under physiologic conditions the enzyme system, microsomal heme-oxygenase, is most active in the spleen followed by the liver and bone marrow, all of which are tissues that normally are involved in the sequestration and metabolism of red cells. Indirect evidence suggested...
متن کاملClxi. Transformation of Haemins into Bile Pigments
THAT bile pigment arises in the body by decomposition of haemoglobin is. generally accepted. The work of Fischer and collaborators has confirmed the close chemical relationship between bilirubin and the colour component of haemoglobin. Hitherto nothing was known about the chemical mechanism of this transformation, nor has the formation of a bile pigment from haemoglobin or haemin in vitro been ...
متن کاملTesting Enzymatic Heme Degradation by Malaria Parasites
Background: Malaria parasites detoxify copious amounts of heme during human infection but enzyme involvement remains unclear. Results: Parasite-infected and uninfected erythrocytes contain indistinguishable low levels of heme catabolites, and a heme oxygenase-like parasite protein binds but does not degrade heme. Conclusion: P. falciparum parasites do not enzymatically degrade heme. Significanc...
متن کاملOrigin of Bile Pigments
S. H. ROBINSON (Boston) described a new experimental technique for studying the early labelled component of bilirubin in the ligated bile duct of the Gunn rat. Using 14C bilirubin he measured the total miscible bilirubin pool. In addition, the rate of bile pigment formation following the administration of 2-14C glycine was estimated. This allowed precise assessment of bilirubin and haem product...
متن کاملBile pigments in the stools of infants.
In the normal person bilirubin is converted in the gut into stercobilin. However, unaltered bile pigment occurs in meconium and in the stool of any individual with much intestinal hurry, and has also been shown to be passed at times by some older infants, though this fact does not seem to be widely known. The absence of stercobilin from the stool is usually takenasevidence for total biliary obs...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy
سال: 1966
ISSN: 0021-4280
DOI: 10.2183/pjab1945.42.966